The primary purpose of this program is to provide basic support for our broadly based experimental, clinical and therapeutic studies. The therapeutic approaches include chemotherapy, immunotherapy, supportive care including blood component transfusions. This grant will provide certain basic resources for this program. Specifically, these will include various basic pharmacologic and experimental therapeutic studies, clinical and laboratory cell population kinetic studies and cell biology studies, and immunologic studies. Development and extension of techniques for data collection, retrieval and continuous analysis of clinical and clinical research material is becoming increasingly important in this program.